Detecting Selection at a Molecular Level

Key Points of Investigation

How do we identify selection at a molecular level?

  • Measuring inter-specific divergence of a protein

*Uses dN/dS ratio to measure divergence, keeps confounding variables constant (such as varying mutational rates due to differences across taxa, or protein involved)

  • Intra-specific polymorphism in a protein
    • Cannot prove selection because it requires different alleles, and in sexually reproducing organisms …

Does the selectionist model differ considering locus-driven selection versus genome wide selection?

Week 9